Trials

Below are listed a number of orthopaedic/ MSK trials that are ongoing (and completed)
across the UK.

This is a living document, and if you wish to contact us to update any of the information
below, or if you wish for your trial/ study to be included, please contact
academic@bota.org.uk

Listed at the end are trials that we are unaware of their status. If you have any further
information, please contact us and we would be happy to update the database.

Beneath this table is network of deaneries that you may wish to contact to ask for further
information about collaboratives and trials.

Project Title	Acronym	Project Leads	Contact	Website	Recruitment Closes	Final Dates	Associations	PMID/ DOI
Surgery Or Rehabilitation for Traumatic shouldEr Dislocations	SORTED	Prof Steve Gwilym	TBC	TBC	TBC	Apr 2033	BESS
Safety And effectiveness of tranexamic acid in acute BuRns Excision	SABRE	Alexander Baldwin, Ganesh Rajaratnam	SabreStudy@gmail.com	https://reconstructivesurgerytrials.net/sabre/	TBC	TBC
Fix Or Replace Enhancing distal humeruS fracTure outcomes	FOREST	Ben Ollivere	forest@nottingham.ac.uk	https://www.nctu.ac.uk/our-research/randomised-trials/current-studies/forest.aspx	Recruiting Centres		NCTU/ BESS
Prophylactic Peri-operative Antibiotics in K-Wire Fixation	PPAK	Sohail Nasir	ppak.bota@gmail.com	https://reconstructivesurgerytrials.net/ppak/	Recruiting Centres
The STernal infEction and RecoNstrUctive Management	STERNUM	Ian King, Joshua Totty	sternumstudy@gmail.com	https://reconstructivesurgerytrials.net/sternum/	Recruiting Centres
THrough knee AMputation’s impact on Quality of Life compared to AbovE Knee AmputaTion	HAMLET	George Smith	ytu-hamlet-trial@york.ac.uk	https://www.york.ac.uk/healthsciences/research/trials/ytutrialsandstudies/trials/hamlet/	Mar 2028	Mar 2030	YTU
The Meniscal Transport Surgery or Opitimised Rehabilitation	METEOR 2	Prof Andrew Metcalfe & Mr Tim Spalding	METEOR2@warwick.ac.uk	https://warwick.ac.uk/fac/sci/med/research/ctu/trials/meteor2/	Nov 2027	Sep 2035	WCTU/ BOSTAA
ACL Stratified Accelerated Repair or Reconstruction	ACL STARR	David Beard, Stephen McDonnell	https://aclstarr.com/	https://aclstarr.com/	Jun 2027		BOSTAA/ OCTRU
Randomised Evaluation of rehabilitation after ACute proximal Humerus fracture	REACH	David Keane	reach@ndorms.ox.ac.uk	https://www.isrctn.com/ISRCTN11914287	Dec 2026	Aug 2027	BESS
Surgery compared with sling immobilisation in the management of adults with a displaced fracture of the distal clavicle: a multi-centre, pragmatic, parallel-group, non-inferiority, randomised controlled trial	DIDACT	Harvinder Singh	ytu-didact@york.ac.uk	https://www.york.ac.uk/healthsciences/research/trials/ytutrialsandstudies/trials/didact/	Dec 2026		YTU/ BESS
Outcomes of Displaced Distal tibial fractures - Surgery Or Casts in KidS	ODD-SOCKS	Nick Peterson	ODDSocks@ndorms.ox.ac.uk	https://oddsocks-study.digitrial.com/	Dec 2026	May 2027	OCTRU
FORENSIC-UK Study: spinal fusion surgery or non-surgical treatment?	FORENSIC-UK	David Beard	forensic@ndorms.ox.ac.uk	https://forensic.octru.ox.ac.uk/	Oct 2026		OCTRU/ BASS
Surgery Versus Conservative OsteOarthritis of Thumb Trial	SCOOTT	Emma Reay, NIck Johnson	ytu-scoott-trial@york.ac.uk	https://www.york.ac.uk/healthsciences/research/trials/ytutrialsandstudies/trials/scoott/	Jun 2026	June 2028	YTU
Genicular Artery Embolisation for the symptomatic treatment of knee osteoarthritis refractory to conservative management	GEKO	Andrew Price	geko@ndorms.ox.ac.uk	https://www.ndorms.ox.ac.uk/research/clinical-trials/current-trials-and-studies/geko	Jun 2026		OCTRU
Reverse or Anatomical replacement for Painful Shoulder Osteoarthritis	RAPSODI	Prof Ian Trail and Prof Jo Dias	ytu-rapsodi@york.ac.uk	https://www.york.ac.uk/healthsciences/research/trials/ytutrialsandstudies/trials/rapsodi/	Apr 2026	Apr 2027	YTU/ BESS
Clinical effectiveness of a child-specific dynamic stretching programme, compared to usual care, for ambulant children with spastic cerebral palsy	SPELL	Tim Theologis	spell@ndorms.ox.ac.uk	https://spell-study.org/	Feb 2026		OCTRU
Clinical effectiveness of an adolescent-specific strengthening programme, compared to usual care, for ambulant adolescents with spastic cerebral palsy	ROBUST	Sally Hopewell	robust@ndorms.ox.ac.uk	https://robust-study.org/	Feb 2026		OCTRU
Severe Necrosing Soft Tissue Infections Audit	SENSEI	Ryo Yoshimura	senseiaudit@gmail.com	https://reconstructivesurgerytrials.net/sensei/	Dec 2025	Dec 2026
Recurrent Patellar Dislocation: Personalised Therapy or Operative Treatment	REPPORT	Prof Andy Metcalfe & Prof Toby Smith	REPPORT@warwick.ac.uk	https://warwick.ac.uk/fac/sci/med/research/ctu/trials/repport/	Dec 2025	Dec 2027	WCTU/ BOSTAA
PERI-operative biologic DMARD management: Stoppage or COntinuation during orthoPaEdic operations	PERISCOPE	Andrew Mott	periscope-group@york.ac.uk	https://www.york.ac.uk/healthsciences/research/trials/ytutrialsandstudies/trials/periscope/ https://www.isrctn.com/ISRCTNISRCTN17691638	Nov 2025	Dec 2026	YTU
An investigation of people 60 years and over with a broken hip to determine whether they are less likely to have delirium after hip surgery if we treat them with infliximab during the operation	WHiTE13-DECI	Prof Matthew Costa	white13-deci@ndorms.ox.ac.uk	https://www.ndorms.ox.ac.uk/research/clinical-trials/white-13-deci-1	Sep 2025	Feb 2027	OCTRU
Ecological Momentary Computerised Adaptive Testing	EMCAT	Conrad Harrison		https://www.isrctn.com/ISRCTN47966791	Jul 2025	Dec 2026	OCTRU
World Hip Trauma Evaluation - Lidocaine Intravenous Trial: a feasibility study for a randomised controlled trial of the effect of intravenous lidocaine at the time of surgery on outcomes following hip fracture	WHiTE10-LIT	Prof Matthew Costa	white10-lit@ndorms.ox.ac.uk	https://www.ndorms.ox.ac.uk/research/clinical-trials/current-trials-and-studies/white10	May 2025	Dec 2026	OCTRU
FLexor repair And REhabilitation Trial	FLARE	Matthew Gardiner, Emma Reay	ytu-flare-trial@york.ac.uk	https://reconstructivesurgerytrials.net/clinical-trials/flare/	Apr 2025	Mar 2026	South Tees
Distal Radius Acute Fracture Trial - Cast vs Splint	DRAFT3-CASP	Prof Matthew Costa	draft3-casp@ndorms.ox.ac.uk	https://draft3.digitrial.com/		Sept 2026	OCTRU
The Fractured Ankle Management Evaluation	FAME	Prof Xavier Griffin	fame@ndorms.ox.ac.uk	https://www.fame-study.digitrial.com/	Closed	2028	OCTRU
The British Orthopaedic Stable SCFE Study	BigBOSS	Dan Perry, Tim Theologis	BigBOSS@ndorms.ox.ac.uk	https://bigboss-study.digitrial.com/taking-part/	Closed	2028	OCTRU
Occupational support for Patients undergoing Arthroplasty of the Lower limb trial	OPAL2	Lesley Sinclair	opal-group@york.ac.uk	https://www.southtees.nhs.uk/about/strive/research-team/aces/world-leading/present/opal2/	Closed	Jan 2026	YTU
Big Toe OstEoarthritis Trial: Inserts	BigTOE	Prof Michael Backhouse, Prof Julie Bruce	bigtoetrial@warwick.ac.uk	https://warwick.ac.uk/fac/sci/med/research/ctu/trials/bigtoe/		Nov 2027	WCTU/ BOSTAA
Prophylactic Antibiotics in Complex Trauma	PACT	Prof Matthew Costa, Jamie Hind	UKPACTStudy@gmail.com
Identifying the incidence of Distal RadioUlnar joInt Dislocations	UK DRUID	Joseph Fennely	https://www.darfi.net/contact/ A.Gomaa@liverpool.ac.uk	https://www.darfi.net/studies/uk-druid/	Closed	Aug 2025	DARFI
A RCT assessing the effectiveness of internal plate fixation versus external fine wire fixation for the management of Type C, closed pilon fractures of the distal tibia	ACTIVE	Steven Brealey	stephen.brealey@york.ac.uk	https://www.york.ac.uk/healthsciences/research/trials/ytutrialsandstudies/trials/active/	Closed	Apr 2025	YTU	PMID: 24385638
Humeral Shaft Fracture Trial	HUSH	Prof Steve Gwilym	hush@ndorms.ox.ac.uk	https://hush-trial.digitrial.com/	Closed	?Feb 2025	BESS	PMID: 38643977
FACT-1 - Talus Fractures	FACT-1	Edward Gee	https://www.darfi.net/contact/	https://www.darfi.net/studies/fact-1/	Closed	Nov 2024	DARFI
Suture fixation versus tension band wiring for simple olecranon fracture fixation: a multi-centre randomised controlled trial	SOFFT	Prof Adam Watts	sophie.j.james@york.ac.uk	https://www.york.ac.uk/healthsciences/research/trials/ytutrialsandstudies/trials/sofft/	Closed	Apr 2024	YTU/ BESS
PROximal Fracture of the Humerus 2	PROFHER 2	Amar Rangan	catherine.arundel@york.ac.uk	https://www.york.ac.uk/healthsciences/research/trials/ytutrialsandstudies/trials/profher-2/	Closed	Dec 2023	YTU/ BESS
Hand And Wrist Trauma: Antimicrobials and Infection - Audit of Clinical Practice	HAWAII-ACP	Justin Wormald, Prof Matthew Costa, Jonathan Cook	RSTNHAWAIIACP@gmail.com	https://www.ndorms.ox.ac.uk/research/clinical-trials/current-trials-and-studies/hawaii	Closed	2023	OCTRU	PMID: 37758504
Repair of digital nerve injury	NEON	Abhilash Jain, Jonathon Cook	NEON@ndorms.ox.ac.uk	https://www.ndorms.ox.ac.uk/research/clinical-trials/current-trials-and-studies/neon	Closed	Dec 2023	OCTRU/ BSSH
Shoulder Pain: Randomised trial of Injectable Treatments) A randomised feasibility and pilot study of Autologous Protein Solution (APS) vs Corticosteroids for treating subacromial shoulder pain	SPIRIT	Prof Steve Gwilym	spirit@ndorms.ox.ac.uk	https://www.ndorms.ox.ac.uk/research/clinical-trials/completed-trials/spirit	Closed	Jun 2023	BESS
Dupuytren's Interventions: Surgery vs Collagenase Trial	DISC	Joseph Dias, Puvan Tharmanathan	puvan.nathan@york.ac.uk		Closed		YTU
Cerebral Palsy in the British Orthopaedic Surgery Surveillance Study	CPinBOSS	Tim Theologis, David Beard	cpboss@ndorms.ox.ac.uk	https://www.ndorms.ox.ac.uk/research/clinical-trials/current-trials-and-studies/cpinboss-study	Closed		OCTRU
Development of a Patient Reported Outcome measure for Lower LImb reconsTruction	PROLLIT	Prof Catherine Hewitt	heather.leggett@york.ac.uk jennie.lister@york.ac.uk	https://www.york.ac.uk/healthsciences/research/trials/ytutrialsandstudies/trials/prollit/	Closed	Phase 1 2021 Phases 2&3 TBC	YTU	PMID: 34465199
Fix or Replace Undisplaced Intracapsular fractures Trial of Interventions	FRUITI	Prof Xavier Griffin				Dec 2028	OCTRU
Thromboprophylaxis in Lower Limb Immobilisation	TiLLI	Daniel Horner, Prof Xavier Griffin	boneandjointhealth@qmul.ac.uk	https://bonejointhealth.ac.uk/thromboprophylaxis-in-lower-limb-immobilisation-tilli/		Aug 2028
An external pilot randomised trial of Delirium Prevention in Fragility Hip Fractures with Corticosteroids.	WHiTE16-DELPHIC	Prof Iain Moppett		https://fundingawards.nihr.ac.uk/award/NIHR206655		May 2027
Mixed Methods Evaluation of the high-volume low-complexity surgical hUb pRogrammE	MEASURE	Prof Joy Adamson		https://measure-study.org/		Apr 2027	YTU
Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers: a randomised non-inferiority trial.	HAND-2	Prof Tim Davis	hand2@nottingham.ac.uk	https://www.hand2.ac.uk/home.aspx		Mar 2026	NCTU
Ulnar Collateral Ligament Trial Evaluating Assessment and Reconstruction	UCLTEAR	Mark Mikhai, Ben Dean	UCLTEAR@gmail.com	https://reconstructivesurgerytrials.net/ucltear/	Surveying		BSSH
No Dates Known
Local ANaesThEtic with adReNaline	LANTERN	Simpson Shiu Chung Tam, Matthew Gardiner	research.prassa@gmail.com	https://www.prassauk.com/copy-of-edips
A feasibility study of a non-surgical joint distraction orthosis for the treatment of thumb base osteoarthritis	DISTRACT	Matthew Gardiner, David Beard	distract@ndorms.ox.ac.uk	https://www.ndorms.ox.ac.uk/research/clinical-trials/current-trials-and-studies/distract			OCTRU
UK Traumatic Anterior Shoulder Dislocation Study	UK TASH-D	Prof Jonathan Rees		https://www.ndorms.ox.ac.uk/research/clinical-trials/completed-trials/shoulder-dislocation			BESS
Perioperative Iron and EPO Intervention Study	POP-I	Prof Iain Moppett	pop-i@nottingham.ac.uk	https://www.nottingham.ac.uk/POP-I/			NCTU
More Information Required
Micro-sampling in Fracture Related Infection	MIST-FRI		ap.khajuria@googlemail.com
Trigger	TRIGGER	Matthew Gardiner	triggertrial@gmail.com				BAPRAS